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Latest Parkinson’s puzzle piece could mean earlier diagnosis | Researchers have found immune cells that are active long before Parkinson's symptoms appear
Researchers have uncovered another piece of the Parkinson’s disease puzzle, identifying that particular immune cells are active long before the hallmark motor symptoms become apparent. It paves the way for the development of earlier diagnostic tools.
“We see these reactive T cells in people after they develop Parkinson’s, but what happens before that?” said Emil Johansson, PhD, the study’s lead author and a visiting scientist who worked in the lab of LJI Professor Alessandro Sette. “Certainly, the fact that this T cell reactivity is highest when patients are closest to a diagnosis is intriguing,” said corresponding author Professor Alessandro Sette, head of the immunology lab at LJI that bears his name. Nonetheless, if these immune markers are the body’s “early warning system” for PD, the study’s findings have the potential to guide the development of a diagnostic tool that identifies the disease long before symptoms appear.
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