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Long Fatigue: The exhaustion that lingers after an infection
Before long Covid there was post-viral fatigue – a mysterious set of illnesses caused by other infections. Now scientists are starting to unravel its secrets.
David Putrino, a professor in the department of rehabilitation and human performance at the Icahn School of Medicine at Mount Sinai, believes that there are at least 10 different plausible explanations for why people develop PEM, which range from sleep disruption to hormonal impairments and inflammation of the lining of blood vessels. Over several decades of studying people with ME/CFS, Betsy Keller, a professor in the department of exercise and sport sciences at Ithaca College in New York, has heard the phrase "mitochondrial dysfunction" cited repeatedly as a possible cause of their prolonged fatigue. At Mount Sinai, Putrino is now leading a clinical trial looking at whether an enzyme called lumbrokinase, which breaks down fibrin, a protein which is thought to be at the core of micro-clots, can help improve mitochondrial function and energy levels in long Covid and ME/CFS patients.
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