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Mapping the half-billion connections that allow mice to see
After nine years of painstaking work, an international team of researchers on Wednesday published a precise map of the vision centers of a mouse brain,
So they had the animal run on a treadmill while watching dynamic 10-second scenes, clips from The Matrix, Mad Max: Fury Road, the Qatsi experimental documentary trilogy, and various extreme sports including motorcross, base jumping and luge. Image by Tyler Sloan, Quarametrix StudioSeung’s team then applied artificial intelligence to trace every contour of every neuron through these tens of thousands of slices, coloring them in to illuminate them individually, a process called segmentation. Seung and Macrina have since launched a company called Zetta AI that performs some of the most painstaking parts of the connectome mapping process for research groups — aligning the images, tracing the neurons’ many branches, and proofreading the results.
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