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Mass General Cancer Center Researchers Identify Gene That Helps Cancer Cells Spread Throughout the Body
The findings could lead to new strategies to treat metastatic cancer and would be particularly impactful for patients with pancreatic cancer.
A new study led by investigators from the Mass General Cancer Center has identified a gene whose expression confers a growth advantage to these cells. Authorship: Christina M. Ferrer, Ruben Boon, Hyo Min Cho, Tiziano Bernasocchi, Lai Ping Wong, Murat Cetinbas, Elizabeth R. Haggerty, Irene Mitsiades, Gregory R. Wojtkiewic, Daniel E. McLoughlin, Reem Aboushousha, Hend Abdelhamid, Sita Kugel, Esther Rheinbay, Ruslan Sadreyev, Dejan Juric, Yvonne M. Janssen-Heininger, and Raul Mostoslavsky. Paper cited: Ferrer CM et al. “The glutathione S-transferase Gstt1 drives survival and dissemination in metastases.” Nature Cell Biology DOI: 10.1038/s41556-024-01426-7
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