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Mice grow bigger brains when given this stretch of human DNA


Finding adds to the bigger picture of how humans developed such large brains.

This study goes deeper than previous work that attempted to unpick the genetic mechanisms behind human brain development, says Katherine Pollard, a bioinformatics researcher at the Gladstone Institute of Data Science and Biotechnology in San Francisco, California. How the human brain grew to be so big and complex remains a mystery, says Gabriel Santpere BarĂ³, a neuroscientist who studies genomics at the Hospital del Mar Medical Research Institute in Barcelona, Spain. But the exact mechanisms that underlie the brain-building effects of HARs are yet to be uncovered, says study co-author Debra Silver, a developmental neurobiologist at Duke University in Durham, North Carolina.

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