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Mice live longer when inflammation-boosting protein is blocked


Humans also have the protein, called IL-11, offering hope for a future longevity treatment.

Although a research team tested for these health effects only in mice, IL-11 and its molecular partners — which include chemical messengers for the immune system called interleukins — also exist in humans. Still, IL-11’s clear path to testing in humans distinguishes it from the crowd of other proteins and rejuvenation interventions, many of which have shown promise in animal models but stalled on the way to clinical trials. But the link between the protein and ageing was discovered by accident when Cook’s colleague, molecular biologist Anissa Widjaja, also at Duke–National University of Singapore Medical School, was testing a method for detecting IL-11.

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