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MIT's one-shot vaccine could deliver robust protection from HIV | Using a combination of two powerful adjuvants, researchers at MIT have come up with a strong vaccine that could prove effective against HIV and other diseases
Researchers at Massachusetts Institute of Technology (MIT) have developed a way to 'supercharge' vaccines to the extent that just a single dose can provide strong protection from HIV.
The MIT team, which collaborated with the medicine-focused Scripps Research Institute, focused on the latter, and actually combined two adjuvants to elicit a significantly better immune response than a vaccine with just either of them. Indeed, the new approach caused the dual-adjuvant vaccine to accumulate in the mice's lymph nodes and stay there for a month, during which time their immune systems effectively built up plenty of antibodies against the HIV protein. "What’s potentially powerful about this approach is that you can achieve long-term exposures based on a combination of adjuvants that are already reasonably well-understood, so it doesn’t require a different technology," chemical engineering professor J. Christopher Love remarked.
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