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Molecule restores cognition and memory in Alzheimer's disease mouse study
A compound jump-started memory circuitry in mice and could treat several disorders if proven effective in humans.
In a new study, a molecule identified and synthesized by UCLA Health researchers was shown to restore cognitive functions in mice with symptoms of Alzheimer’s disease by effectively jump-starting the brain’s memory circuitry. In the study, published in the Proceedings of the National Academy of Sciences, UCLA researchers led by Dr. Istvan Mody and Dr. Varghese John, a professor of neurology and director of the Drug Discovery Laboratory (DDL) at the Mary S. Easton Center for Alzheimer’s Disease Research and Care at UCLA sought to find a compound that could figuratively flip the switch back on in the brain’s memory circuitry. Should it ultimately prove to be effective, the drug could have implications for treatments of other diseases and health conditions that have diminished gamma oscillations, such as depression, schizophrenia and autism spectrum disorder, Mody said.
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