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Mushroom Supplements Are the Biohackers’ Latest Fix (2025)


Curious about mushroom supplements? Here's what they do, what the science says, and how to know if they're right for you—according to the experts.

In a study in Singapore, participants who ate more than two cups of mushrooms (golden, oyster, shiitake, and white button) a week had a 50 percent lower risk of developing mild cognitive impairment. Marketed as brain food, lion’s mane is rich in terpenes like hericenones and erinacines that boost the production of the Nerve Growth Factor(NGF), a protein vital for the maintenance and regeneration of neurons. Behind their umami-rich bite is a potent wellness profile: these mushrooms deliver lentinan, an immune-boosting polysaccharide, and eritadenine, known for supporting heart health by lowering cholesterol.

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