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New imaging technique reveals early stages of how amyloid-beta plaques form in the brain; molecule is believed to play a key role in Alzheimer's disease
Researchers at Washington University in St. Louis have used microscopy to chart amyloid beta’s underlying structure and yield insight into neurodegenerative disease.
Transiently binding and flashing Nile blue (NB) molecules enable the nanoscale architectures of growing and decaying regions in fibrils to be visualized as these multicolored forks. “The way A-beta behaves in a variety of environments, including the human brain, is elusive,” said Brian Sun, an electrical systems and engineering alumnus of Washington University in St. Louis who is now an MD/PhD student at the School of Medicine. Sun credits McKelvey Engineering and the Lew lab for the rigorous training that made this study and academic trajectory possible, as well as the MSTP for supporting his continued research post-graduation.
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