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New protein therapy shows promise as antidote for carbon monoxide poisoning
University of Maryland School of Medicine (UMSOM) researchers, along with their colleagues, engineered a new molecule that appears promising as an effective antidote for carbon monoxide poisoning with fewer side effects than other molecules currently being tested, according to a new study published in the journal PNAS. Carbon monoxide poisoning accounts for 50,000 emergency room visits in the U.S.
“Unlike other protein-based treatments, we found the compound caused only minimal changes in blood pressure, which was an exciting finding and raised the potential for this new molecule to have clinical applications,” said study corresponding author Mark T. Gladwin, MD, Dean of UMSOM who is also the Vice President for Medical Affairs, University of Maryland, Baltimore (UMB), and the John Z. and Akiko K. Bowers Distinguished Professor. All too often, patients are not transported, diagnosed, and treated in time to reverse the effects of carbon monoxide poisoning, which can cause lasting cardiac and neurological injuries or even death. Dr. Rose and Dean Gladwin are co-founders and directors of Globin Solutions, which has licensed technology based on RcoM from the University of Pittsburgh towards the development of a CO poisoning antidote.
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