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New technique sheds light on memory and learning
Less than twenty minutes after finishing this article, your brain will begin to store the information that you’ve just read in a coordinated burst of neuronal activity. Underpinning this process is a phenomenon known as dendritic translation, which involves an uptick in localized protein production within dendrites, the spiny branches that project off the neuron […]
“Hacisuleyman’s work defines a whole new biochemical pathway which fits with, complements, and vastly expands what we already knew about memory and learning,” adds Darnell, the Robert and Harriet Heilbrunn professor. That system, it turns out, lies at the heart of how our brains form memories and learn new information, and became a focus for the Darnell lab, culminating in his team’s 2003 development of CLIP, a method that allowed researchers to study the proteins that bind and influence RNA. To get a better idea of the role that changes in dendrites play in learning, Hacisuleyman extended the TurboID platform to works in concert with RNA-sequencing, CLIP, translation and protein analysis.
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