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Newfound Mechanism Rewires Cellular Energy Processing for Drastic Weight Loss
NYU Langone Health researchers have learned that eliminating the amino acid cysteine caused drastic weight loss in mice.
Led by researchers at NYU Grossman School of Medicine, the study reveals key details about how cells process fuels like carbohydrates and fats (metabolism), and how cysteine depletion affects tissues. “Given that achieving maximum cysteine deprivation weight loss in the mice was dependent on both diet and deletion of the gene, moving forward we can now restore cysteine production genetically in specific cells or tissues and determine the role of each in the dramatic weight loss we observed,” said co-senior author Dan R. Littman, MD, PhD, the Helen L. and Martin S. Kimmel Professor of Molecular Immunology in the Department of Pathology, and a professor in the Department of Cell Biology, at NYU Grossman School of Medicine. The study also shows that ISR and OSR, acting independently of CoA depletion, also increase the production of the stress hormone GDF15, which contributes to food aversion and degradation of acetyl-CoA-carboxylase, a key enzyme in lipid biosynthesis.
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