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NMDA Receptor Antagonists: Slightly More Than You Wanted to Know
Insights from Memantine and Ketamine's divergent effects on the Brain
I’m sticking to my theme of writing about the NMDA Receptor, this time explaining why NMDAR Antagonists can anesthetize you, treat your alzheimers, or cure your depression Using drugs with this protein complex seems to inherently lead to bizarre phenomena on both the level of the neuron (see; Hebbia, Homeostatica, and Magnesia) and the brain as a whole (see; Elon’s twitter feed). For instance, Ketamine is anesthetic because at high doses it never comes unbound, whereas Memantine dissociates from the receptor every single time the central pore opens.
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