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Non-Hallucinogenic LSD Analogue Shows Promise for Psychiatry
UC Davis researchers developed JRT, a modified version of LSD that promotes neuroplasticity without hallucinogenic effects. Tested in mice, JRT enhanced brain connectivity, showed antidepressant effects and improved cognition.
By promoting dendritic growth, increasing synaptic density and enhancing cortical connectivity, psychedelics exhibit powerful neuroplastic effects that may help reverse the structural brain changes seen in conditions such as depression, post-traumatic stress disorder (PTSD), addiction and schizophrenia. Prior studies have suggested that certain parts of the LSD molecule are responsible for triggering hallucinations – specifically, a small chemical group that forms a key interaction with brain receptors. JRT’s ability to promote the growth of brain cell connections – combined with its antidepressant and cognition-enhancing effects in animal studies – suggests it could help with these harder-to-treat aspects of schizophrenia.
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