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NYU develops new drug that attacks cancer cells without harming healthy ones | The researchers say the new technique may lead to new ways to treat patients with some cancers with minimal side effects.
Researchers at NYU Langone Health developed a new drug that targets mutant HER2 cancer proteins without harming healthy cells.
But despite causing major diseases, these slightly mutated proteins can resemble their normal versions so closely that treatments designed to target mutants could also harm healthy cells. Cancer can also result when cells accidentally make extra copies of the DNA instructions that code for the normal version of HER2 and express higher protein levels on their surfaces. Published online October 22 in the journal Nature Chemical Biology, the study shows how the researchers harnessed their new protein-engineering technique to develop antibodies that recognize only mutant HER2.
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