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Once-a-week pill for schizophrenia shows promise in clinical trials
MIT researchers developed a pill that can be taken once a week instead of daily, gradually releasing medication from within the stomach. In a phase 3 clinical trial, the treatment maintained consistent levels of the drug risperidone in patients with schizophrenia, and it controlled their symptoms just as well as daily doses of the drug.
In a phase 3 clinical trial conducted by MIT spinout Lyndra Therapeutics, the researchers used the once-a-week pill to deliver a widely used medication for managing the symptoms of schizophrenia. Traverso’s lab began developing the ingestible capsule studied in this trial more than 10 years ago, as part of an ongoing effort to make medications easier for patients to take. The MIT and Lyndra team chose to focus on schizophrenia in hopes that a drug regimen that could be administered less frequently, through oral delivery, could make treatment easier for patients and their caregivers.
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