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One-dose nasal spray clears toxic Alzheimer's proteins to improve memory
One dose of a new treatment, delivered by nasal spray, clears away build-ups of the toxic tau protein associated with Alzheimer’s disease from inside brain cells, improving memory, according to new research. It paves the way for new treatments for the debilitating disease.
“This nasal spray approach opens new avenues for non-invasive delivery of tau therapeutic antibodies directly to the brain, and it holds promise for many neurogenerative diseases,” said Dr. Rakez Kayed, professor at the Department of Neurology at UTMB and the study’s corresponding author. Loaded into micelles, aggregates of molecules that are both water-loving (hydrophilic) and fat-loving (lipophilic), that are delivered intranasally means the treatment quickly arrives in the brain via the nose-to-brain anatomical pathway, bypassing the BBB completely. “This advancement could significantly impact the treatment strategies for Alzheimer’s and related tauopathies, offering new hope for millions of patients suffering from these debilitating conditions,” said Sagar Gaikwad, the study’s first author and a postdoctoral fellow at UTMB.
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