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Ozempic is changing people's skin, say plastic surgeons


“It becomes like an old, overused rubberband.”

While operating on Ozempic patients, Dr. Few started to notice a trend: The skin quality of someone on a GLP-1 was reminding him of an “old, overused rubber band.” Mark Mofid, MD, a board-certified facial plastic surgeon in San Diego and La Jolla, makes a similar comparison—it’s like the elastic waistband on a pair of underwear that has stretched out over time. In her practice, Umbareen Mahmood, a board-certified plastic surgeon in New York City, has noticed “accelerated aging in the face” of patients who have lost a considerable amount of weight on a GLP-1, noting “increased fine lines, jowling, periorbital hollowness, and crepiness of the skin.” But skin changes are also showing up on arms, legs, and stomachs. Dr. Mahmood is also seeing a “significantly greater number” of younger patients who have been on a GLP-1 asking for injectables and non-surgical collagen-boosting treatments like radiofrequency microneedling on the face and neck to help stimulate collagen and elastin production.

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