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Pain pathway in a dish opens the door to better chronic pain treatments | The discovery allows scientists to better understand chronic pain and how pain perception is affected by conditions like autism and offers an animal-free method of testing pain treatments.
Four tiny 3D organs connected themselves in a lab dish, forming a replica of the human pain pathway, in a new study. The discovery allows scientists to better understand chronic pain and how pain perception is affected by conditions like autism and offers an animal-free method of testing pain…
Disruptions to this pathway, caused by genetics or environmental factors, can lead to chronic pain or the sensory hypersensitivity that often accompanies autism spectrum disorder (ASD). “We can now model this pathway non-invasively,” said Dr Sergiu Pașca, professor of psychiatry and behavioral sciences at Stanford University and the study’s corresponding author. Genetic mutations that affect Nav1.7, a particular type of sodium channel found predominantly on peripheral sensory neurons, can lead to either a debilitating hypersensitivity to pain or an inability to experience it.
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