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Pancreatic cancer vaccine eradicates trace of disease in early trials
We could be on the verge of a major cancer treatment breakthrough, with a new vaccine shown to completely obliterate pancreatic cancer cells in preclinical trials. This paves the way for it to move onto the human trial stage.
The treatment centers around targeting the most common mutations seen in PDAC tumor cells, using nanoparticles loaded with antigens that trigger the immune system to attack and destroy the cancer growth. "Our central hypothesis is that innovative nanosized therapeutic cancer vaccines, specifically targeting multiple mutant oncogenes in pancreatic ductal adenocarcinoma (PDAC), could potentially overcome tumor heterogeneity, thereby achieving a high rate of disease-free survival," the researchers wrote. "To non- invasively assess the therapeutic impact of these nano-vaccines, we will utilize cutting-edge magnetic resonance molecular imaging (MRMI) technology," the team wrote in a project outline.
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