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Parkinson's treatment closer as problematic protein imaged for first time | Known as PINK1, the protein has been linked to the disease for decades but its structure and how to switch it back on have remained elusive – until now.
Scientists have finally pinned down a protein that’s largely responsible for Parkinson’s disease. Known as PINK1, the protein has been linked to the disease for decades but its structure and how to switch it back on have remained elusive – until now.
PINK1’s role in Parkinson’s has been known for a long time, but frustratingly the protein’s structure, and how it attaches to mitochondria, have remained a mystery. Now, researchers at WEHI in Australia have managed to image the structure of PINK1 attached to mitochondria for the first time, using cryo-electron microscopes. “Our structure reveals many new ways to change PINK1, essentially switching it on, which will be life-changing for people with Parkinson’s,” said Professor David Komander, corresponding author of the study.
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