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Powerful new oral painkiller blocks signals without sedation or addiction
Scientists have shown the efficacy of a new non-opioid oral painkiller known as ADRIANA, the world's first selective α2B-adrenoceptor antagonist – a receptor subtype not previously targeted for analgesics. In clinical trials so far, it has provided powerful pain relief without sedation or risk of…
Scientists have shown the efficacy of a new non-opioid oral painkiller known as ADRIANA, the world's first selective α2B-adrenoceptor antagonist – a receptor subtype not previously targeted for analgesics. The researchers found how a2B becomes more active after nerve injury, and in mice was able to perform the genetic knockout required to inhibit a2B, significantly shutting down neuropathic pain in the animals. Clinical trials at Kyoto University Hospital found that the drug was both safe and tolerable, and effective for patients with postoperative pain following lung cancer surgery.
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