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Princeton researchers bend DNA strands with light to probe the genome


By turning droplets into tools for physically repositioning DNA, scientists can now explore gene expression with unprecedented precision.

Scientists are studying gene expression to increasingly new depths, which holds promise for locating disease before it starts or the precise mechanism that’s causing dysfunction in the first place. They compare the new tool to CRISPR technology, except it doesn’t edit the gene but opens up a new way to understand and possibly treat certain classes of disease, specifically related to protein imbalances, such as cancer. By manipulating DNA strands with liquid droplets, researchers could transform our genetic functions, correct inherent flaws, and create a more harmonious biological composition.

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