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Remote-controlled gene therapy uses ultrasound to kill cancer
A new kind of cancer gene therapy can be remotely activated at a specific part of the body. The team developed a version of CRISPR that responds to ultrasound, and demonstrated how it can be used to clear cancer in mice.
The problem is, it doesn’t always stay in the right part of the body, and can continue editing genes long after it’s needed, potentially triggering an immune response. To use this tool to fight cancer, the team set CRISPR to target telomeres, the repeating DNA sequences on the ends of chromosomes. The team says that future work should focus on improving the technique and potentially extending it beyond CAR T cell therapy.
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