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Researchers discover antibody capable of neutralizing venom from a wide variety of snake species across the globe; discovery may lead to universal antidote for snakebites
Snaking toward a universal antivenom Scripps Research scientists discovered antibodies that protect against a host of lethal snake venoms. February 21, 2024 LA JOLLA, CA—Scripps Research scientists have developed an antibody that can block the effects of lethal toxins in the venoms of a wide variety of snakes found throughout Africa, Asia and Australia.
LA JOLLA, CA— Scripps Research scientists have developed an antibody that can block the effects of lethal toxins in the venoms of a wide variety of snakes found throughout Africa, Asia and Australia. “This antibody works against one of the major toxins found across numerous snake species that contribute to tens of thousands of deaths every year,” says senior author Joseph Jardine, PhD, assistant professor of immunology and microbiology at Scripps Research. In addition to Khalek and Jardine, authors of the study, “ Synthetic development of abroadly neutralizing antibody against snake venom long-chain α-neurotoxins,” include Yen Thi Kim Nguyen, Jordan Woehl, Jessica M. Smith, Karen Saye-Francisco, Yoojin Kim, Laetitia Misson Mindrebo, Quoc Tran, Mateusz Kędzior, Oliver Limbo, Megan Verma, Robyn L. Stanfield, Dennis R. Burton, Devin Sok and Ian A. Wilson of Scripps; Evy Boré, Rohit N. Patel, Stefanie K. Menzies, Stuart Ainsworth, Robert A. Harrison and Nicholas R. Casewell of the Liverpool School of Tropical Medicine; and R. R. Senji Laxme, Suyog Khochare and Kartik Sunagar of the Indian Institute of Science.
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