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Researchers get viable mice by editing DNA from two sperm | Altering chemical modifications of DNA lets the DNA from two sperm make a mouse.
Altering chemical modifications of DNA lets the DNA from two sperm make a mouse.
And, roughly 20 years ago, a team managed to find the right deletion to enable a female mouse to give birth to offspring that received a set of chromosomes from each of two unfertilized eggs. It took until earlier this year, when a very specific combination of 20 different gene edits and deletions enabled mice generated using the chromosomes from two sperm cells to survive to adulthood. But this work has already been useful even in its inefficient state, because it serves as a pretty definitive validation of our ideas about the function of imprinting in embryonic development, as well as the critical role methylation plays in this process.
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