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Researchers tie heart failure to molecules released from fat cells
Heart failure with preserved ejection fraction (known as HFpEF), is the most common kind of heart failure, affecting millions globally. The heart still pumps, it just can't relax and fill appropriately. Think of it like a stiff balloon that won't stretch, blood backs up, pressure builds, and…
This fat isn't just sitting there; it's sending out chemical signals (called adipokines) that can stir up inflammation, raise pressure, and mess with how the heart relaxes. The Adipokine Hypothesis emphasizes the therapeutic potential of targeting dysfunctional fat tissue, not just to reduce its volume, but to restore its beneficial signaling profile. Notably, GLP-1 receptor agonists such as semaglutide and tirzepatide have shown promise in modulating adipokine release, shifting the balance toward anti-inflammatory and cardioprotective profiles.
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