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Scientists Discover How Pancreatic Cancer Switches Off a 'Tumor Suppressor' Gene
An anonymous reader shared this report from the Guardian: A team of researchers from the UK and US have found that pancreatic cancer is able to shut down molecules in one of the body's most important genes, helping the disease to grow and spread rapidly... Dr Maria Hatziapostolou, of Nottingham T...
An anonymous reader shared this report from the Guardian: A team of researchers from the UK and US have found that pancreatic cancer is able to shut down molecules in one of the body's most important genes, helping the disease to grow and spread rapidly... Dr Maria Hatziapostolou, of Nottingham Trent University's John van Geest Cancer Research Centre, said: "This work, which has provided new understanding and knowledge of how the cancer behaves, will hopefully help pave the way for potential new treatments in the future...." For the study, published in the journal Gastro Hep Advances, the researchers analysed healthy as well as pancreatic cancer tissue samples. They found pancreatic cancers triggered a process known as DNA methylation, causing molecules in the normally beneficial HNF4A gene to switch off, allowing tumours to grow extremely quickly. Hatziapostolou said: "Loss of HNF4A drives pancreatic cancer development and aggressiveness and we now know correlates with poor patient survival."
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