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Scientists Discover Why Alcohol Blocks Liver Regeneration, Even After You Quit
Alcohol damages the liver by disrupting RNA splicing, leaving cells stuck between functional and regenerative states. Targeting inflammation and restoring ESRP2 may provide new treatment options. Heavy alcohol use can interfere with the liver’s natural ability to repair itself by leaving cells st
So they try to regenerate, and they’re all ending up in this unproductive quasi-progenitor state, and that’s what is causing liver failure,” said U. of I. graduate students Ullas Chembazhi and Sushant Bangru, the co-first authors of the study. “In comparing the samples, we saw RNA was getting misspliced broadly in alcohol-related liver disease, across thousands of genes, and it was affecting major functions of proteins,” said Kalsotra, who also is affiliated with the Carl R. Woese Institute for Genomic Biology at Illinois. Reference: “Dysregulated RNA splicing impairs regeneration in alcohol-associated liver disease” by Ullas V. Chembazhi, Sushant Bangru, Rajesh Kumar Dutta, Diptatanu Das, Brandon Peiffer, Subhashis Natua, Katelyn Toohill, Aurelia Leona, Ishita Purwar, Anuprova Bhowmik, Yogesh Goyal, Zhaoli Sun, Anna Mae Diehl and Auinash Kalsotra, 10 September 2025, Nature Communications.
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