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Scientists glue two proteins together, driving cancer cells to self-destruct
Stanford researchers hope new technique will flip lymphoma protein’s normal action — from preventing cell death to triggering it.
A new molecule developed by Stanford Medicine researchers (turquoise and yellow) tethers two proteins (purple and red) that together switch on self-destruction genes in cancer cells. The idea came to Gerald Crabtree, MD, a professor of development biology, during a pandemic stroll through the forests of Kings Mountain, west of Palo Alto, California. To harness cells’ natural and highly specific self-destruction abilities, the team developed a kind of molecular glue that sticks together two proteins that normally would have nothing to do with one another.
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