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Scientists grow ‘mini-organs’ from cells shed by foetuses in womb
Creating organoids from cells found in amniotic fluid could bring insights into cause and progression of malformations
They created the 3D lumps of tissue know as organoids from lung, kidney and intestinal cells recovered from the amniotic fluid that bathes and protects the foetus in the uterus. Dr Mattia Gerli, a stem cell researcher at UCL, said foetal organoids, which are less than a millimetre wide, would allow scientists to study how foetuses develop in the womb “in both health and disease”, a feat that has so far not been possible. Writing in Nature Medicine, Gerli and Prof Paolo de Coppi, a foetal surgeon at Great Ormond Street Institute of Child Health, describe how they analysed amniotic fluid taken from 12 pregnant women as part of their routine diagnostic testing.
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