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Scientists Have Finally Identified Where Gluten Intolerance Begins
For roughly one in every hundred people, food containing even the smallest amounts of gluten can deliver a gutful of hurt.
Using transgenic mice, an international team led by scientists from McMasters University in Canada has identified a crucial role played by the very cells making up the gut's lining, describing a major stepping stone that could lead to new therapies. They then created functional living models of the gut, called an organoid, using the mouse intestinal cells in order to study the expression of their immune proteins up close, subjecting them to inflammatory triggers as well as predigested and intact gluten. Knowing the types of tissue involved and their enhancement by the presence of inflammatory microbes gives researchers a new list of targets for future treatments, potentially allowing millions of people worldwide to enjoy a gluten-filled pastry or two without the risk of discomfort.
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