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Scientists Say They've Discovered How Cancer Hijacks and Corrupts Immune Cells
How cancer cells learn to dodge immune attacks has puzzled scientists for decades. A new study offers a surprising answer.
In tests in petri dishes and mice, the team found that blocking this mitochondria swap slowed cancer growth and made a common immunotherapy more effective. This swapping “is a newly discovered mechanism that thwarts anticancer defenses,” wrote Jonathan Brestoff at Washington University School of Medicine, who was also not part of the study. Analyzing clinical data from roughly 200 people with two types of cancer, the team found that increased mtDNA mutation was associated with worse outcomes, even when the patients were receiving immunotherapy treatments.
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