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SDR42E1 modulates Vitamin D absorption and cancer pathogenesis
IntroductionVitamin D is a pleiotropic hormone essential for bone health and overall physiological function. Despite its significance, vitamin D deficiency r...
Our recent research, utilizing clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) gene-editing technology in skin keratinocytes, demonstrated that SDR42E1 depletion disrupts the steroid biosynthesis, leading to accumulation of 7-DHC and a concomitant reduction in vitamin D levels. These observations warrant further experimental validation through assays, such as Annexin V staining, apoptosis and cell cycle analysis—and mechanistic studies exploring the roles of chromatin remodeling and non-coding RNAs in mediating SDR42E1 ’s effects on vitamin D signaling and cancer-related pathways. Zhang Y, Li CN, Jiang WD, Wu P, Liu Y, Kuang SY, et al. An emerging role of vitamin D(3) in amino acid absorption in different intestinal segments of on-growing grass carp (Ctenopharyngodon idella).
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