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Sequencing wastewater may be key to getting a grip on the H5N1 bird flu outbreak


Opinion: It’s time to take a new approach to monitoring the H5N1 outbreak in dairy cows.

Sequencing showed the virus to be from the clade circulating among dairy cows, but did not detect a mutation adaptive for human transmission, consistent with animals as the source. This type of approach, if decentralized closer to farms and scaled to urban centers, could provide nationwide visibility into H5N1’s geographic distribution and genomic evolution and help get a handle on transmission. Efforts to create a pared-down protocol of this kind could be pursued, but has not taken place at any level of scale to our knowledge and would need to be validated before wider use, which could take months and require substantial funding to complete.

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