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Simulating C. elegans brain, body and environment interactions
BAAIWorm is an integrative data-driven model of C. elegans that simulates interactions between the brain, body and environment. The biophysically detailed neuronal model is capable of replicating the zigzag movement observed in this species.
The large-scale 3D environment allows the integration of various agents and elements including C. elegans, Escherichia coli(food) and fluid, and it provides a range of auxiliary tools for various lighting effects, visualization, tracking and behavior analysis. In all the perturbation scenarios, the body exhibits a higher degree of twisting during locomotion, as indicated by the larger relative locations of tracking points on the head and tail compared with the control group (Fig. In the future, we will improve the optimization algorithm to effectively train larger detailed neural networks that contain all 302 neurons, with more constraints such as single-neuron voltages, and reproduce more behaviors beyond zigzag locomotion.
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