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Targeting Brain's Drainage Pathways Rejuvenates Memory
Rejuvenating the brain's lymphatic vessels can enhance memory in aging mice by improving the removal of waste products from the brain.
Credit: Neuroscience NewsThe study, published online March 21 in the journal Cell, lays the groundwork to develop therapies for age-related cognitive decline that overcome the challenges faced by conventional medications that struggle to pass through the blood-brain barrier to reach the brain. “The physical blood-brain barrier hinders the efficacy of therapies for neurological disorders,” said Jonathan Kipnis, PhD, the Alan A. and Edith L. Wolff Distinguished Professor of Pathology & Immunology and a BJC Investigator at WashU Medicine. A decade ago, Kipnis’ lab discovered a network of vessels surrounding the brain — known as the meningeal lymphatics — in mice and humans that drains fluid and waste into the lymph nodes, where many immune system cells reside and monitor for signs of infection, disease or injury.
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