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TAU makes breakthrough in drug delivery to treat inflammatory bowel disease
To present the pioneering concept, Peer and his team encoded the anti-inflammatory protein interleukin-10 into mRNA and delivered it to animal models with Crohn's disease.
About seven million people around the world and 15% of the US population suffer from inflammatory bowel disease (IBD), most of them developing their first signs before the age of 40, and many of them recalling the onset of symptoms during childhood or young adulthood. The team members have successfully transported lipid nanoparticles encapsulating messenger RNA (mRNA) to the immune system of the small and large intestines bypassing the liver. Just changing the composition of the nanoparticles, the researchers showed that mRNA-based drugs can be directed straight to target cells, avoiding the liver.
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