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The Academic Culture of Fraud

In 2006, Sylvain Lesné and seven coauthors published a paper on Alzheimer’s disease, “A specific amyloid-beta protein assembly in the brain impairs memory,” in Nature, the world’s most prestigious scientific journal. This was a major paper in the development of the “amyloid hypothesis,” a proposed mechanism for how Alzheimer’s disease afflicts its victims.

In 2023, Marc Tessier-Lavigne, then the President of Stanford University, was forced to resign after the revelation of falsified data in his earlier research at drug developer Genentech, including a now-retracted paper on the amyloid hypothesis which has been cited over 1,000 times. The culture encourages this at every step of the way, starting with PhD candidates ordered to produce a positive result by any means necessary, continuing with coauthors and grantmakers who can’t be bothered to look at the data and check whether it makes any sense, all the way to department heads and famous bestsellers being widely cited even after they’ve been caught. They were in dialogue not through formal academic institutions but through loose informal networks of peers, like the “Invisible College” and the “Republic of Letters.” It was in these distributed conversations that modern science was developed and codified, and made its first major discoveries, establishing the intellectual authority of its practitioners.

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