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The Cause of Alzheimer's Might Not Be Amyloid
New research from Emory University suggests that proteins accumulating around amyloid-beta deposits, rather than the deposits themselves, may play a crucial role in the progression of Alzheimer's disease, offering new directions for treatment. Recent research from Emory University is prompting a
In a paper published in the journal Cell Reports Medicine, Todd E. Golde and Yona Levites explain how the amyloid beta deposits long known to build up in the brains of Alzheimer’s patients serve as a kind of scaffold for the accumulation of other proteins. While the basics of Alzheimer’s have been understood for more than a century, the search for a cure has been slow, often marked by repeated cycles of initially promising treatments that didn’t work in trials, as well as continuing controversy over competing theories to best explain how the disease damages the brain. Reference: “Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer’s disease” by Yona Levites, Eric B. Dammer, Yong Ran, Wangchen Tsering, Duc Duong, Measho Abreha, Joshna Gadhavi, Kiara Lolo, Jorge Trejo-Lopez, Jennifer Phillips, Andrea Iturbe, Aya Erquizi, Brenda D. Moore, Danny Ryu, Aditya Natu, Kristy Dillon, Jose Torrellas, Corey Moran, Thomas Ladd, Farhana Afroz, Tariful Islam, Jaishree Jagirdar, Cory C. Funk, Max Robinson, Srikant Rangaraju, David R. Borchelt, Nilüfer Ertekin-Taner, Jeffrey W. Kelly, Frank L. Heppner, Erik C.B.
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