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Tumor-targeting Salmonella engineered to boost colon cancer survival | Scientists have engineered a species of Salmonella that self-destructs inside colon cancer tumors
Scientists have engineered Salmonella bacteria to self-destruct inside tumors, releasing signals that spark powerful immune hubs and shrink colon cancer in mice, opening the door to “living medicines” against deadly cancers.
“Our engineered strain stimulates a key immune signaling pathway, LIGHT-HVEM, to activate group 3 innate lymphoid cells and kickstart T cell-mediated antitumor responses.” Nonetheless, if the findings are translatable to humans, this approach could provide a new therapeutic angle, using a living engineered bacterium that colonizes tumors and delivers immune-stimulating molecules on-site. “This approach could pave the way for programmable ‘living medicines’ that reshape the tumor environment from within,” said Pengfei Rong, MD, PhD, the study’s other corresponding author, from the Third Xianguya Hospital, Central South University.
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