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Two HIV vaccine trials show proof of concept for pathway to broadly neutralizing antibodies

Learn more about North American and African clinical trials led by Scripps Research, IAVI and collaborators that show early immune activation using mRNA vaccine technology—marking progress toward an effective HIV vaccine.

“These incredibly exciting results underscore the importance and capability of global partnerships to drive cutting-edge science,” says Julien Nyombayire, executive director of the Center for Family Health Research in Kigali, Rwanda, and one of the lead principal investigators of G003. In addition to Schief and Nyombayire, authors of the study, “ Vaccination with mRNA-encoded nanoparticles drives early maturation of HIV bnAb precursors in humans, ” include Yumiko Adachi, Nushin Alavi, Sonya Amirzehni, Sabyasachi Baboo, Christopher A. Cottrell, Jolene Diedrich, Claudia Flynn, Erik Georgeson, Grace Gibson, Alessia Liguori, Katherine McKenney, Oleksandr Kalyuzhniy, Michael Kubitz, Elise Landais, Jeong Hyun Lee, Danny Lu, Gabriel Ozorowski, James C. Paulson, Nicole Phelps, Swastik Phulera, Torben Schiffner, Troy Sincomb, Ryan Tingle, Andrew B. Hunt, Allison Kennedy, Nahid R. Keshavarzi, Vincent Muturi-Kioi, Dominick Laddy, Dagna S. Laufer, Mabela Matsoso, Linda M. Murungi, Ansuya Naidoo, Jennifer Santos, Melissa Schroeter, Marisa Shields, Devin Sok, Kristen Syvertsen and Johan Vekemans of IAVI; Erica Beatman, Allan C. deCamp, Michael Duff, Drienna Holman, Ollivier Hyrien, Gabrielle Lemire, Ju Yeong Kim, Soo-Young Kim, Kellie J. MacPhee, M. Juliana McElrath, Janine Maenza, Adrienne E. Shapiro and Amanda Tsai of the Fred Hutchinson Cancer Center; Hongmei Gao, Kelli Greene, David Montefiori, Caleb Kibet, Georgia Tomaras and Nicole L. Yates of Duke University; Martin M. Corcoran, Gunilla B. Karlsson Hedestam and Isabel Regadas of Karolinska Institutet; Omu Anzala, Ruth Chirchir, Daniel Muema and Joel Musando of KAVI; Baoyu Ding, Chunla He, Sunny Himansu, Brett Leav, Li-An Lin, Caroline Reuter and Walter L. Straus of Moderna Inc.; David M. Brown of the Foundation for the National Institutes of Health; Adrian B. McDermott of Sanofi; Pholo Maenetje and Edward Vinodh of the Rustenburg Research Centre; Rosine Ingabire, Etienne Karita of the Center for Family Health Research; Srilatha Edupuganti of Emory University; Barbara S. Taylor of The University of Texas Health Science Center at San Antonio; and David Diemert of The George Washington University.

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