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Type 1 diabetes reversed by new cell transplantation technique
Transplanting insulin-producing cells along with engineered blood-vessel-forming cells has successfully reversed type 1 diabetes, according to a new preclinical study. With further testing, the novel approach could one day cure the as-yet incurable condition.
“This work lays the foundation for subcutaneous [under the skin] islet transplants as a relatively safe and durable treatment option for type 1 diabetes,” said the study’s lead author, Ge Li, PhD, a research associate at WCM’s Department of Medicine. “Ultimately, the potential of surgical implantation of these vascularized islets needs to be examined for their safety and efficacy in additional preclinical models,” said co-author Dr Rebecca Craig-Schapiro, associate professor of surgery at Weill Cornell. “[T]ranslation of this technology to treat patients with type 1 diabetes will require circumventing numerous hurdles, including scaling up sufficient numbers of vascularized islets, and devising approaches to avoid immunosuppression,” said Li.
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