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Under-skin implant dispenses naloxone to prevent opioid overdose deaths | The iSOS (Implantable System for Opioid Safety) implant is being developed to automatically dispenses naloxone from within the body.
When someone overdoses on opioids, it's critically important that they receive a dose of the opioid-reversing drug naloxone as soon as possible – otherwise, death is a distinct possibility. That's where a new implant comes in, as it automatically dispenses naloxone from within the body.
It contains 10 milligrams of naloxone in an integrated reservoir, plus it incorporates electronics such as a battery, vibrator and Bluetooth module, plus multiple ECG electrodes and a suite of other sensors. Given the fact that the drug lasts for at least 14 days at body temperature, it is envisioned that patients would simply visit a clinic once every two weeks for a battery charge and a refill. While we have seen non-implant wearables designed for use by opioid addicts who want to survive accidental overdoses, the team behind the iSOS state that those systems typically don't deliver a sufficient naloxone dosage fast enough.
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