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Using MRI, engineers have found a way to detect light deep in the brain. The new technique could enable detailed studies of how brain cells develop and communicate with each other.


A new way to detect bioluminescence in the brain uses magnetic resonance imaging (MRI). The technique, developed at MIT, could enable researchers to explore the inner workings of the brain in more detail than previously possible.

Jasanoff, who is also an associate investigator at MIT’s McGovern Institute for Brain Research, is the senior author of the study, which appears today in Nature Biomedical Engineering. To make the blood vessels sensitive to light, the researcher engineered them to express a bacterial protein called Beggiatoa photoactivated adenylate cyclase (bPAC). Once the blood vessels were sensitized to light, the researchers implanted cells that had been engineered to express luciferase if a substrate called CZT is present.

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