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What causes migraines? Study of 'brain blackout' offers clues
The blinding headaches are poorly understood — a mouse study suggests that the content of spinal fluid is a trigger for pain.
This altered fluid, researchers suggest, travels through a previously unknown gap in anatomy to nerves in the skull where it activates pain and inflammatory receptors, causing headaches. But how the brain, which is not directly linked to the peripheral nervous system, triggers nerves to cause headaches is poorly understood, making them difficult to treat. Dussor suggests that future studies should explore why the proteins in spinal fluid that hit the trigeminal ganglion result in headaches and no other type of pain.
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