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World-first "undruggable" cancer treatment enters human trial | Novel cancer drug PMR-116 will be put to the test in a world first trial in 2025
A promising new treatment to combat "undruggable" cancers has been green-lit for a human trial in 2025. It's hoped the novel drug will be able to stunt the growth and enable the effective treatment of cancers driven by the MYC oncogene and its MYC protein.
The study – led by The Australian National University (ANU) and Canberra Health Services – will be a "basket trial," enrolling patients with different kinds of cancers – just ones that have the MYC driver fueling them. "Pol I transcription of ribosomal RNA genes (rDNA) is tightly regulated downstream of oncogenic pathways, and its dysregulation is a common feature in cancer and other human diseases. “Our goal with this trial is to target a key driver of cancer, and speed development to get effective treatments to patients sooner," he added.
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