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World-first obesity pill reprograms fat cells to burn calories with zero effort | The first human-tested weight-loss drug that burns calories through creatine-based heat generation, without reducing appetite, has successfully completed its Phase I trial.
The first human-tested weight-loss drug that burns calories through creatine-based heat generation, without reducing appetite, has successfully completed its Phase I trial.
“This result opens a completely new therapeutic pathway for obesity and metabolic disorders – one that complements GLP-1 therapies but focuses on enhancing the body’s energy-burning capacity rather than just suppressing appetite,” said Carlos Escande, researcher at IP Montevideo and a member of Eolo Pharma. “This work has been a constant challenge, and it’s incredibly rewarding to see that the human trial results follow the same trend we observed in our lab models,” said Karina Cal, lead author of the study, researcher at IP Montevideo, and member of Eolo Pharma. In the comprehensive preclinical mice study, SANA boosted thermogenic energy expenditure via a pathway involving creatine metabolism, not the usual UCP1 (uncoupling protein 1) route that scientists have so far been investigating in this sort of " fat-burning pill" research.
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