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World-first therapy using donor cells sends autoimmune diseases into remission
The treatment’s success in three people raises hopes for mass production of cutting-edge CAR T therapies.
Instead of making one treatment for one person, therapies for more than a hundred people could be made from one donor’s cells, says Lin Xin, an immunologist at Tsinghua University in Beijing. The success and safety of the therapy look promising but still need to be demonstrated in many more people before researchers can draw conclusions about its broad application, says Christina Bergmann, a rheumatologist at the University Hospital Erlangen in Germany. None of the individuals experienced an extreme inflammatory reaction known as cytokine-release syndrome, which has been observed in some people with cancer who have received CAR-T therapy, and they didn’t show evidence of the graft attacking the host.
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